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In the modern review, we claimed the identification as well as the characterization of a whole new atypical opioid receptor with one of a kind negative regulatory Attributes toward opioid peptides.1 Our benefits showed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a wide-spectrum scaven